CBD and Side Effects

CBD and Side Effects

Cannabidiol has great benefits for the body but rarely can it also result in some mild side effects. There is a lot of talk about the benefits derived from cannabidiol (CBD) but almost never about its side effects.

Often, in fact, the narrative that is made about the side effects of CBD is anecdotally derived and has its basis in the stereotype that has enveloped the hemp plant for decades.

Cannabidiol (CBD) is one of the main active ingredients in the hem plant. It has no psychotropic effect, unlike Delta-9-tetrahydrocannabinol (THC), another of the active ingredients. As a result, side effects include no alteration in perceptual abilities.

According to the WHO report, cannabidiol has a good safety profile and is well tolerated by humans and animals. In addition, again according to the report, CBD has no psychoactive effects, does not induce physical dependence, and is not associated with any adverse public health effects.

The therapeutic properties of CBD.

CBD (Cannabidiol) has gained in these years a lot of importance for its application in the therapeutic field.
Thanks to its interaction with the Endocannabinoid System, which is responsible for modulating mechanisms already existing and in place in our body, it tends to restore the original balance when an imbalance occurs, such as an inflammatory state or another type of trauma.

Cannabidiol (CBD) therefore involves an indirect modulation of an alteration in the human endocannabinoid system caused by disease or trauma.

Before we talk about CBD side effects, let’s then do a quick overview of what the therapeutic properties are:

  • Analgesic and anti-inflammatory properties: it reduces the perception of pain thanks to its action on the endocannabinoid system present in the human body.
  • Anxiolytic properties: it has been shown to mitigate the symptoms associated with Post Traumatic Stress Disorder (PTSD) and Obsessive Compulsive Disorder (OCD), which according to several researches are also caused by a deficiency of anandamide in the human endocannabinoid system.
  • Neuroprotective properties: Cannabidiol has been shown to have potential action in reducing oxidative stress that can affect brain cells, thanks in part to its anti-inflammatory properties.
  • Antipsychotic properties: Some scientific evidence suggests that cannabidiol helps treat schizophrenia and other mental health problems, such as bipolar disorder.
  • Anti-emetic properties: CBD oils can easily reduce this disorder, effectively treating the symptoms of rejection. CBD oils are easily digestible, contain no chemical components, and do not give off the unpleasant flavors of regular antiemetic drugs, which are rich in antacids and bismuth.
  • Anticonvulsant properties: CBD would be very effective in therapies to treat some forms of childhood epilepsy, including Dravet Syndrome.
  • Energizing and antioxidant properties: known for its calming effects, CBD also offers energizing properties, thanks to its detoxinanate action and ability to strengthen the cells of the human body, contributing to their proper regeneration.

In the face of such a wide variety of actions, the questions that people often ask about hemp and, specifically, about cannabidiol (CBD) concern precisely the possible side effects of CBD.

Let’s see which are the cases considered by science and research.

Side effects of CBD: drowsiness

Some studies that aimed to investigate various effects of CBD on humans have highlighted the possibility that it can induce drowsiness. However, other investigations have reported how cannabidiol can also be a very useful ally for those people who suffer from insomnia. In this case, a fundamental factor is the condition for which one decides to take CBD. If it is the case of sleep disorders, then this side effect is no more.

Side effects of CBD: interaction with hepatic drugs

Cannabidiol has an effect on metabolism, and in particular, it may have an effect on medications that some people take due to certain liver conditions.

These drugs, in general, are metabolized by the enzyme called CY3A4, the same enzyme that is involved in the metabolism of CBD.

This implies that some medications aimed at inhibiting this enzyme, may also slow down the absorption and breakdown of CBD. Other medications, on the other hand, increase the levels of this enzyme and CBD is broken down much more quickly as a result. In the case of people with liver disease and treated with specific medications, it is best to consult with a medical professional to assess the potential interaction with CBD.

Side effects of CBD: dry mouth

In a research carried out in 1986 by the staff of the Department of Pharmacology and Toxicology of the University of Arizona, the effects of CBD were investigated on five patients suffering from dystonia: a motor difficulty due to involuntary postural attitudes of the individual.

CBD side effects: fatigue or weakness

Researchers at the University of Nottingham published the results of a study in which they described the effects found in nine volunteers (adults and male) who were given a massive dose of cannabidiol (CBD): as much as 600 milligrams.

Researchers observed a marked decrease in participants’ blood pressure, who also described feeling tired and dizzy due to this very lowering.

Cannabidiol can help lower blood pressure (but remember that the study was looking at the effects of a particularly high dose of cannabidiol). It is for this reason that people suffering from low blood pressure should consider their dosage especially carefully, to avoid experiencing those unpleasant sensations.

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